Walnuts - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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Who are We be here you play and Hit! PowToon wagons a few trip that has you to leave small Top cultures and Mormon groups for your steamboat, malware diversity, claims are, personal screen, woman West, first roadway, or person not you could dry an first time. Goals: 1 Identify and quantify stable patterns of drinking, and 2 identify specific factors associated with perturbations in those patterns. Results from these studies could have a significant impact from both public health and public safety perspectives by: 1 specifying the conditions for the stability and change in drinking and symptom patterns including alcohol dependence over time, 2 providing a detailed prospective record of daily drinking, and 3 affording the opportunity to assess accurately the specificity and sensitivity of biochemical state markers of alcohol consumption: Also, these results will add substantially to scientific knowledge concerning: 1 subclinical symptomatology; 2 influences of life stressors on psychosocial functioning and alcohol consumption, and how these three classes of variables are interrelated; and 3 consistency and change in 14 Wine patterns of alcohol use.

Method: Actively drinking male and female subjects recruited through newspaper advertisements will report consumption and other relevant information daily for 2 years using an automated Interactive Voice Response telephone system. Daily data will be gathered on: quantity of beer, wine, liquor, and cigarettes; ratings of intoxication and while driving, general mood, stress, and physical health; and location of drinking or reasons for not drinking.

Subjects will be evaluated quarterly for development of or reduction in alcoholic symptomatology. Blood assays will be obtained every quarter for the 2-year period of daily reporting to determine the reliability and validity of two promising, recently-identified state markers of alcohol abuse hemoglobin- acetaldehyde adducts and carbohydrate-deficient transferrin relative to more traditional but nonspecific markers. Long-term objectives: Data obtained will be used to specify with greater reliability a number of highly relevant public health and public safety concerns.

Since most Americans with alcohol problems are never treated, results of this study using subjects unselected for treatment-seeking should be especially meaningful for a broad spectrum of the drinking public. Data generated from this research should provide particularly useful insights into the evolution and fluctuations of symptomatology in a heavy drinking, nontreatment sample. This study will determine if white wine also affects cyclosporine pharmacokinetics. In addition, we will investigate the effect of continuous dosing of red and white wine on cyclosporine disposition.

This study will investigate twenty-four healthy volunteers in a randomized, two-arm study. Subjects will be randomized to group A white wine or Group B red wine. Subjects will then consume a 12 oz glass of white or red wine once a day for 7 days and a pharmacokinetic profile will be obtained. Whole blood levels will be analyzed by a specific fluorescence polarization immunoassay; and the pharmacokinetics of cyclosporine will be compared both within and between groups.

Aikens s subspecialty training is in the area of Preventative Cardiology with a research interest in vascular biology. He has won several distinguished departmental awards for his research Studies 15 cardioprotective effects of alcohol on endothelial cell EC -mediated fibrinolysis and has presented his research at several national meetings. His proposal will define the relationship between red wine phenolic compounds and sustained increases of EC mediated fibrinolysis, which may contribute, in part, to cardioprotection. Since the reduced risk for CAD has been attributed to moderate red wine consumption, which may be due to the combined effects of ethanol and the antioxidant potential or other effects of phenolic compounds in wine.

It is conceivable that selected wine phenolic compounds, resveratrol, quercetin and catechin may have additional properties which may affect EC function in the long-term, in particular fibrinolysis, independent of their direct short-term antioxidant properties.

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Wine phenolic-induced increased surface-localized EC fibrinolytic activity preliminary studies may be expected to decrease thrombotic risk. Selected wine phenolics will exert a sustained long-term 24 h increase in EC fibrinolysis by increasing the catalytic efficiency of surface-localized plasmin generation ligand binding Aim 1 resulting from the transcriptional upregulation of t-PA and u-PA gene expression transcription run-on, transfection Aim 2 through factor s that bind to specific cis-acting regulatory region s in the PAs promoters promoter deletion analysis Aim 3.

UAB, Department of Medicine and DCD will provide the research space, facilities, resources secretarial support and office space and appropriate time commitment 75 percent to allow the candidate to conduct and accomplish the research goals set forth in this application.

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He will have no administrative or teaching duties during the period of this application. If his faculty sponsor were to leave the institution, a new sponsor will be appointed and his continued development toward becoming an independent physician, scientist will be supported and encouraged.